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Fatal pseudomembranous enterocolitis following clindamycin therapy
The British Journal of Surgery
|April 1, 1976
Abstract:
A fatal case of pseudomembranous enterocolitis following oral and parenteral clindamycin therapy is presented. Interesting features in this case are involvement of the small bowel and complete sparing of the large bowel distal to a defunctioning transverse colostomy. The significance of the absence of disease in the defunctioned bowel is discussed in terms of aetiology and diagnosis of pseudomembranous enterocolitis.
Insights
A fatal case of pseudomembranous enterocolitis occurred after clindamycin treatment. The small bowel was affected, but the defunctioned large bowel was spared, offering insights into the condition's causes.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Pseudomembranous enterocolitis is a severe gastrointestinal condition often associated with antibiotic use.
- Clindamycin is a known trigger for this potentially life-threatening condition.
Observation:
- This case details a fatal instance of pseudomembranous enterocolitis following both oral and parenteral clindamycin administration.
- A unique feature was the exclusive involvement of the small bowel, with the large bowel distal to a transverse colostomy remaining unaffected.
Findings:
- The disease pattern challenges typical presentations, highlighting the small bowel as a potential primary site.
- Complete sparing of the defunctioned bowel suggests a role for luminal factors or microbial activity in disease pathogenesis.
Implications:
- Understanding this atypical presentation can refine diagnostic approaches to pseudomembranous enterocolitis.
- Further research into the etiological factors, particularly concerning bowel segments and antibiotic exposure, is warranted.