Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacokinetic determinants of the window of selection for antimalarial drug resistance.

Antimicrobial agents and chemotherapy·2008
Same author

Comparison of characteristics of admitted emergency department patients requiring cardiopulmonary resuscitation in the ICU and non-ICU setting.

Emergency medicine journal : EMJ·2008
Same author

Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2008
Same author

Population pharmacokinetics of piperaquine after two different treatment regimens with dihydroartemisinin-piperaquine in patients with Plasmodium falciparum malaria in Thailand.

Antimicrobial agents and chemotherapy·2008
Same author

Plasmodium knowlesi: the fifth human malaria parasite.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2008
Same author

Direct in vivo assessment of microcirculatory dysfunction in severe falciparum malaria.

The Journal of infectious diseases·2008

Related Experiment Video

Updated: Jul 7, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Melioidosis.

N J White1

  • 1Faculty of Tropical Medicine, Mahidol University, 10400, Bangkok, Thailand. fnnjw@diamond.mahidol.ac.th <fnnjw@diamond.mahidol.ac.th>

Lancet (London, England)
|May 28, 2003
PubMed
Summary

Melioidosis, a serious bacterial infection, causes significant sepsis and mortality in Asia and Australia. Early recognition and effective treatment are crucial for improving patient outcomes and reducing relapse rates.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, is a major cause of sepsis in East Asia and Northern Australia.
  • The bacterium is an environmental saprophyte found in wet soils, primarily infecting adults with predisposing conditions like diabetes.
  • Disease presentation varies, including abscess formation in multiple organs and, in some cases, brain stem encephalitis.

Purpose of the Study:

  • To summarize the epidemiology, clinical manifestations, and treatment of melioidosis.
  • To highlight the challenges in managing this serious infection, including slow treatment response and high relapse rates.

Main Methods:

  • Review of existing literature on melioidosis.
  • Analysis of epidemiological data from endemic regions.

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Related Experiment Videos

Last Updated: Jul 7, 2026

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

  • Summary of current treatment guidelines and outcomes.

    • Main Results:

    • Melioidosis accounts for 20% of community-acquired septicaemias in northeastern Thailand, with a 40% mortality rate in treated patients.
    • Ceftazidime is the primary treatment for severe cases, but fever abatement is slow (median 9 days).
    • Relapse occurs in 10% of patients despite prolonged antibiotic therapy.

    Conclusions:

    • Melioidosis remains a significant public health concern in endemic areas.
    • Improved diagnostics and healthcare, coupled with increased travel, will likely lead to more frequent recognition of melioidosis globally.
    • Further research into optimizing treatment strategies and reducing relapse rates is warranted.