Current concepts of the inflammatory response after major trauma: an update
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Updated: Sep 25, 2026

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
Published on: June 10, 2020
1Department of Trauma and Orthopaedic Surgery, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK. pgiannoudi@aol.com
Abstract:
During the past century explosive developments have taken place in the field of molecular medicine and genetics, vastly expanding our understanding of the normal physiological response to injury. We have been able to characterise specific molecular and cell biological processes and apply some of this knowledge to the treatment of multiply injured patients. Despite the significant steps we have made, there still remains much work to be done in this area. This review article highlights the current concepts of post-traumatic immunological changes and their impact in the management of trauma patients.
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