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Renin-angiotensin system and atherothrombotic disease: from genes to treatment

Douglas S Jacoby1, Daniel J Rader

  • 1Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania Health System, 3400 Spruce Street, Philadelphia, PA 19104, USA. douglas.jacoby@uphs.upenn.edu

Archives of Internal Medicine
|May 28, 2003
PubMed

Insights

The renin-angiotensin system drives cardiovascular disease and atherosclerosis. Blocking this system reduces plaque buildup and ischemic events, offering therapeutic potential.

Area of Science:

  • Cardiovascular Science
  • Molecular Biology
  • Genetics

Background:

  • The renin-angiotensin system (RAS) is integral to cardiovascular disease pathogenesis.
  • Angiotensin II, a key RAS peptide, promotes atherosclerosis at molecular and cellular levels.

Purpose of the Study:

  • To provide a comprehensive review of the RAS's role in atherothrombotic disease.
  • To cover molecular pathways, human genetics, and clinical trial data.

Main Methods:

  • Literature review of animal and human studies.
  • Analysis of molecular mechanisms and genetic associations.
  • Synthesis of findings from recent clinical trials.

Main Results:

  • RAS activation contributes significantly to atherosclerotic plaque development.
  • Inhibition of RAS pathways has demonstrated efficacy in reducing plaque progression.
  • Blocking RAS effectively decreases the incidence of ischemic events.

Conclusions:

  • The renin-angiotensin system is a critical target for managing cardiovascular and atherothrombotic diseases.
  • Targeting RAS offers a promising strategy for preventing atherosclerotic plaque progression and related ischemic complications.

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