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Related Experiment Videos

Neural crest and cardiovascular development: a 20-year perspective.

Mary Redmond Hutson1, Margaret L Kirby

  • 1Neonatal-Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA. mhutson@duke.edu

Birth Defects Research. Part C, Embryo Today : Reviews
|May 29, 2003
PubMed
Summary

Neural crest cells are crucial for heart development. New research suggests these cells are part of a larger developmental field, explaining complex congenital heart defects like DiGeorge syndrome.

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Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Craniofacial Development

Background:

  • Twenty years ago, a critical region of neural crest cells essential for cardiovascular development was identified.
  • Ablation of these cells in chick embryos led to severe cardiovascular malformations, including persistent truncus arteriosus and great vessel mispatterning.

Purpose of the Study:

  • To review 20 years of progress in understanding the role of cardiac neural crest cells in cardiovascular and pharyngeal arch development.
  • To explore the molecular pathways governing cardiac neural crest cell development.
  • To reconcile existing models with human congenital heart defect phenotypes.

Main Methods:

  • Historical perspective on cardiac neural crest research.
  • Review of molecular pathways influencing cardiac neural crest cell specification, migration, patterning, and targeting.

Related Experiment Videos

  • Analysis of genetic manipulations and their impact on cardiovascular development models.

    • Main Results:

    • Significant knowledge has been gained regarding cardiac neural crest cell contributions to cardiovascular development.
    • Current models often fail to fully explain phenotypes observed in human congenital heart defects, such as DiGeorge syndrome.
    • The direct and indirect contributions of cardiac neural crest cells are increasingly understood.

    Conclusions:

    • The cardiac neural crest is proposed to be part of a broader cardiocraniofacial morphogenetic field.
    • Abnormal development of this field may underlie several human syndromes associated with congenital heart defects.
    • This broader field concept offers a potential explanation for complex congenital heart defect phenotypes.