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Updated: Aug 16, 2026

Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
[Treatment of traumatic cerebrospinal rhinorrhea in frontal sinus]
1Department of Otorhinolaryngology, Third Hospital of Sun-Yet-Sen University of Medical Sciences, Guangzhou 510630, China. lhb73@263.net
Objective:
To evaluate the indication, operative technique and advantages of the treatment of traumatic cerebrospinal rhinorrhea in frontal sinus by intranasal endoscopic surgery.
Method:
Treatment of 6 cases of traumatic cerebrospinal rhinorrhea in frontal sinus by intranasal endoscopic surgery was reported. We adopt a procedure to open and enlarge the nasofrontal duct under direct vision by intranasal endoscopic surgery firstly and find the fistula, then repair it with its own smashed muscle, and support it with muscular membrane and gelfoam, iodoform Sponges.
Results:
Four cases were repaired successively in one procedure with intranasal endoscopic surgery, 2 cases were solved by combined external and intranasal procedure.
Conclusions:
The advantages of treatment of traumatic cerebrospinal rhinorrhea in frontal sinus by intranasal endoscopic surgery included easily operation, easily confirmation of fistula and high success rate, combination of frontal sinus incision may deal with its demerit to the un-reach-able site sometimes.
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