[Long-term treatment with low molecular weight heparin, of chronic disseminated intravascular coagulation]

Area of Science:

• Cardiovascular Medicine
• Hematology
• Pathology

Background:

• Disseminated intravascular coagulation (DIC) is a complex pathological process involving widespread thrombin and plasmin generation.
• Common causes of DIC include infections and neoplasia, but vascular diseases like aortic aneurysms can also be implicated.
• Aortic aneurysms present a risk factor for developing DIC, complicating patient management.

Observation:

• A patient with chronic DIC and a systemic hemorrhagic syndrome secondary to an aortic aneurysm was treated.
• Initial treatment with low molecular weight heparin (LMWH) was altered due to an allergic reaction, necessitating a switch to a different LMWH.
• Hemorrhagic complications were managed with antifibrinolytics in conjunction with LMWH therapy.

Findings:

• The patient received LMWH treatment for 30 months.
• The treatment regimen resulted in an acceptable performance status.
• The primary adverse effect noted was the development of osteoporosis.

Implications:

• This case demonstrates a potential therapeutic approach for managing DIC associated with aortic aneurysms.
• The use of LMWH and antifibrinolytics can be effective in controlling hemorrhagic complications in DIC.
• Long-term LMWH therapy requires monitoring for potential side effects such as osteoporosis.