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Mitochondria: role in ischemia, reperfusion and cell death
Pedro Monteiro1, Paulo J Oliveira, Lino Gonçalves
1Unidade de Investigação Básica em Cardiologia, Serviço de Cardiologia, Hospitais da Universidade de Coimbra, Clínica de Cardiologia, Faculdade de Medicina, Centro de Neurociências e Biologia Celular de Coimbra, Coimbra.
Abstract:
Recent advances in the knowledge of the biochemical basis of myocardial ischemia have enabled a better understanding of the complex sequence of events occurring in ischemic cardiomyopathy, whatever its manifestations. This has clearly highlighted the important role played by cardiac mitochondria in these events. At first only associated with energy production, mitochondria have been clearly shown to have other important functions, like the maintenance of calcium homeostasis, as well as ischemic and non-ischemic preconditioning, and also modulation of cellular life and death. The aims of this review are twofold: firstly, to review the current knowledge on mitochondrial morphology and structure, and how these can be affected by ischemia and ischemia-reperfusion; and secondly, to summarize the role of cardiac mitochondria in cardioprotection and modulation of cell death mechanisms.