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T cell lymphoma associated with myelofibrosis
Sujatha A Rao1, Susan R S Gottesman, Min C Nguyen
1Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA.
Leukemia & Lymphoma
|May 29, 2003
Summary
Myelofibrosis, typically linked to myeloproliferative disorders, can rarely occur with T-cell lymphoma. Chemotherapy resolved myelofibrosis in a T-cell lymphoma patient, suggesting lymphoma evaluation in fibrotic bone marrow.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Myelofibrosis is a myeloproliferative disorder characterized by bone marrow fibrosis.
- It is predominantly associated with primary myeloproliferative neoplasms.
- Myelofibrosis is rarely documented in lymphoid neoplasms.
Observation:
- This report details the fourth documented case of myelofibrosis associated with T-cell lymphoma.
- The case involved extensive extramedullary hematopoiesis affecting the bone marrow, lymph nodes, and spleen.
- Initial presentation included significant bone marrow fibrosis.
Findings:
- The patient received standard combination chemotherapy for T-cell lymphoma.
- A complete resolution of myelofibrosis was observed following successful lymphoma treatment.
- This indicates a potential direct or indirect link between lymphoma activity and myelofibrosis.
Implications:
- The findings suggest that T-cell lymphoma should be considered in the differential diagnosis of unexplained myelofibrosis.
- Careful evaluation of fibrotic bone marrow specimens for underlying lymphoma is warranted.
- This case highlights the importance of considering lymphoid malignancies in myelofibrotic conditions.