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Related Experiment Videos

Novel immunosuppressive agents in tolerance induction.

N R Krieger1, S J Knechtle

  • 1Division of Organ Transplantation, Department of Surgery, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA.

Current Drug Targets. Cardiovascular & Haematological Disorders
|May 29, 2003
PubMed
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Achieving transplantation tolerance aims to free patients from long-term immunosuppression. Current strategies involve limited immunosuppressive agent use, with promising preliminary data from embryonic stem cells for tolerance induction.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Regenerative Medicine

Background:

  • Induction of transplantation tolerance is a key goal to eliminate lifelong immunosuppression.
  • Current tolerance induction strategies rely on temporary immunosuppressive drug administration.
  • Novel agents and approaches are continuously being explored to improve outcomes.

Purpose of the Study:

  • To review current agents and strategies for inducing transplantation tolerance.
  • To explore the potential of embryonic stem cells in enhancing tolerance induction.
  • To assess the progress and feasibility of clinical transplantation tolerance.

Main Methods:

  • Review of existing literature on immunosuppressive agents for tolerance induction.
  • Categorization of agents into lymphocyte depletion, costimulation blockade, and adjunctive therapies (e.g., rapamycin).

Related Experiment Videos

  • Examination of preliminary data on donor stem cells, including embryonic stem cells, for tolerance induction.

    • Main Results:

    • Various agents, including those targeting lymphocyte depletion and costimulation blockade, are employed.
    • Rapamycin is noted as an adjunctive agent in tolerance induction protocols.
    • Preliminary findings suggest embryonic stem cells may offer advantages over conventional bone marrow for tolerance induction.

    Conclusions:

    • Successful induction of transplantation tolerance can potentially free patients from long-term immunosuppression.
    • Progress in clinical tolerance induction is evident, with achievable results in a subset of patients.
    • Embryonic stem cells show promise as a superior alternative for future tolerance induction strategies.