Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microwave-assisted solid-phase synthesis (MASS): parallel and combinatorial chemical library synthesis.

Fahad Al-Obeidi1, Richard E Austin, John F Okonya

  • 1Aventis Combinatorial Technologies Center (formerly Selectide), 1580 E. Hanley Blvd, Tucson, AZ 85737, USA. Fahad.Al-Obeidi@Aventis.com

Mini Reviews in Medicinal Chemistry
|May 29, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclic Glycopeptide Analogs of Endomorphin-1 Provide Highly Effective Antinociception in Male and Female Mice.

ACS medicinal chemistry letters·2024
Same author

Structure-Based Design of Glycosylated Oxytocin Analogues with Improved Selectivity and Antinociceptive Activity.

ACS medicinal chemistry letters·2023
Same author

Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation.

Cell·2015
Same author

Analysis and prediction of combinatorial chemistry synthesis and screening data.

Combinatorial chemistry & high throughput screening·2006
Same author

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Bioorganic & medicinal chemistry letters·2004
Same author

Using a noncovalent protection strategy to enhance solid-phase synthesis.

Methods in molecular biology (Clifton, N.J.)·2002

Microwave heating significantly accelerates solid-phase organic synthesis, reducing reaction times from hours to minutes. This method enhances product purity by minimizing thermal degradation, making it a valuable tool for efficient chemical synthesis.

Area of Science:

  • Organic Chemistry
  • Chemical Engineering
  • Materials Science

Background:

  • Solid-phase synthesis is a crucial technique in organic chemistry.
  • Conventional heating methods can be time-consuming and lead to product degradation.
  • Microwave technology offers potential improvements in reaction efficiency and product quality.

Purpose of the Study:

  • To explore the advantages of microwave heating in solid-phase organic synthesis.
  • To compare microwave-assisted synthesis with conventional heating techniques.
  • To highlight the impact of microwave irradiation on reaction speed and product purity.

Main Methods:

  • Utilizing microwave irradiation for solid-phase organic reactions.
  • Employing solid supports as reaction media or reagent carriers.

Related Experiment Videos

  • Comparing reaction times and product purity with conventional heating methods.

    • Main Results:

    • Microwave heating dramatically reduces reaction times, often from hours to minutes.
    • Microwave-accelerated reactions yield products with higher purity due to decreased thermal degradation.
    • The selection of reagents, solvents, and equipment is critical for successful microwave-mediated synthesis.

    Conclusions:

    • Microwave irradiation is a powerful and efficient tool for solid-phase organic synthesis.
    • The technique offers significant time savings and improved product quality compared to conventional methods.
    • Microwave-assisted solid-phase synthesis is an emerging and valuable approach in modern chemistry.