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Updated: Jul 23, 2026

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
Published on: March 5, 2017
Review in quantitative structure activity relationships on lipoxygenase inhibitors
Pontiki Eleni1, Hadjipavlou-Litina Dimitra
1Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.
Abstract:
This paper reviews and evaluates all the published QSAR treatments of LOX inhibitors. This reveals that in almost all cases, the clog P parameter plays an important part in the QSAR relationships. In some cases the steric factors (B(1), B(5) and L) as well as the overall molar refractivity (CMR) or the substitutents molar refractivity (MR) are important. Electronic effects except for the Hammet's constant alpha, are comparatively unimportant. The study shows that log P as calculated from the Clog P program is suitable for this form of QSAR study. Log Po of 2.77-3.76 was found to be ideal, for the biological response.
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