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Charminarone, a seco-pseudoguaianolide from Parthenium hysterophorus
B Venkataiah1, C Ramesh, N Ravindranath
1Organic Chemistry Division--I, Indian Institute of Chemical Technology, Hyderabad 500 007, India.
Phytochemistry
|May 29, 2003
Abstract:
A novel sesquiterpenoid, charminarone, the first seco-pseudoguaianolide, has been isolated along with several known compounds from the whole plant of Parthenium hysterophorus. The structure of the new compound has been settled as 1,10-seco-dihydroisoparthenin 1,10-dione from its spectral data as well as from its conversion by reductive coupling reaction with Zn/TiCl(4) reagent to the known compound, anhydrodihydroisoparthenin. The reagent Zn/TiCl(4) has been used here for the first time to construct the seven membered ring of a pseudoguaianolide sesquiterpenoid.