Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Galactosyltransferase--still up and running.

E G Berger1, J Rohrer

  • 1Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. egberger@physiol.unizh.ch

Biochimie
|May 29, 2003
PubMed
Summary

This review covers galactosyltransferase (gal-T1) from discovery to present, highlighting its genetic defect and broad life science impact. Further research on gal-T1 promises insights into cellular processes and development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Chiral Two-Body Currents in ^{6}Li Magnetic Properties in Light of a New Precision Measurement with the Relative Self-Absorption Technique.

Physical review letters·2021
Same author

Role of sonication pre-treatment and cation valence in the sol-gel transition of nano-cellulose suspensions.

Scientific reports·2017
Same author

Thiolated silicone oils as adhesive skin protectants for improved barrier function.

International journal of cosmetic science·2015
Same author

Ab initio structure modelling of complex thin-film oxides: thermodynamical stability of TiC/thin-film alumina.

Journal of physics. Condensed matter : an Institute of Physics journal·2011
Same author

Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition.

Cellular and molecular life sciences : CMLS·2008
Same author

Source-zone characterization of a chlorinated-solvent contaminated Superfund site in Tucson, AZ.

Journal of contaminant hydrology·2006

Area of Science:

  • Biochemistry
  • Cell Biology
  • Genetics
  • Enzymology

Background:

  • Galactosyltransferase (gal-T1) is a key enzyme with diverse roles.
  • Research on gal-T1 spans over 40 years, revealing complex biological functions.
  • A genetic defect in gal-T1 has been identified, underscoring its medical relevance.

Purpose of the Study:

  • To comprehensively review the genetic, biochemical, structural, biotechnological, cell biological, and medical aspects of gal-T1.
  • To trace the evolution of gal-T1 research and its impact on life sciences.
  • To identify unanswered questions and future research directions for gal-T1.

Main Methods:

  • Literature review encompassing historical and current research on galactosyltransferase.
  • Analysis of genetic, biochemical, structural, and cell biological data.
  • Discussion of biotechnological and medical implications.

Main Results:

  • Gal-T1 has been implicated in numerous life science domains.
  • A genetic defect associated with gal-T1 has been discovered.
  • The enzyme's involvement in cellular trafficking, signaling, development, and morphogenesis is evident.

Conclusions:

  • Gal-T1 research offers a fascinating case study in scientific evolution.
  • Despite extensive study, significant questions remain regarding gal-T1's function and regulation.
  • Future research on gal-T1 and its gene family is crucial for advancing understanding of cellular processes and development.

Related Experiment Videos