Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering cancer resistance in mice.

Peter Klatt1, Manuel Serrano

  • 1Spanish National Centre of Biotechnology, Department of Immunology and Oncology, Campus de Cantoblanco, Madrid E-28049, Spain.

Carcinogenesis
|May 29, 2003
PubMed
Summary

Engineering mice for cancer resistance is a novel research area. This review examines models of cancer resistance in mice, focusing on molecular mechanisms and potential health impacts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2.

Nature cancer·2026
Same author

Phase IIB, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID-19.

European journal of haematology·2026
Same author

Evaluation of IVIG for Prevention of Infections Occurring On-study and Treatment of Infection of Solid Organ Recipients With Secondary Antibody Deficiency: A Phase 2 Randomized Clinical Trial.

Transplantation direct·2026
Same author

A targeted metabolomic method to detect epigenetically relevant metabolites.

Molecular metabolism·2026
Same author

Senotoxins target senescence via lipid binding specificity, ion imbalance and lipidome remodeling.

Nature aging·2026
Same author

Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome.

Frontiers in immunology·2025

Area of Science:

  • Oncology
  • Genetics
  • Animal Models

Background:

  • Genetic manipulation of mice has significantly advanced cancer research.
  • Previous research focused on accelerating tumorigenesis or modeling cancer development.
  • A novel approach involves engineering mice for cancer resistance to understand susceptibility.

Purpose of the Study:

  • To review existing mouse models exhibiting a cancer resistance phenotype.
  • To emphasize the molecular underpinnings of cancer resistance.
  • To identify associated phenotypes that could negatively affect health.

Main Methods:

  • Literature review of published studies on cancer-resistant mouse models.
  • Analysis of genetic modifications and their impact on tumorigenesis.
  • Evaluation of associated health phenotypes in engineered mice.

Main Results:

  • Several mouse models with inherent or engineered cancer resistance have been described.
  • The molecular basis for resistance varies across different models.
  • Associated phenotypes, potentially detrimental to health, are frequently observed.

Conclusions:

  • Cancer-resistant mouse models offer valuable insights into cancer susceptibility.
  • These models are crucial for validating therapeutic and chemopreventive strategies.
  • Further research is needed to balance cancer resistance with overall health in these models.

Related Experiment Videos