Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Animal models for asthma: controversial aspects and unsolved problems.

R Pabst1

  • 1Department of Functional and Applied Anatomy, Medical School of Hannover, Hannover, Germany. pabst.reinhard@mh-hannover.de

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
|May 29, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The postnatal development of the compartments in human lymph nodes up to 15 years of age.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2023
Same author

Ceremonies of gratitude following the dissection course: A report on procedures in departments of anatomy in German speaking countries.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2016
Same author

[Start-up grants for young scientists in German medical universities : Can the clinical scientist be saved?]

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2016
Same author

[Surgery as specialization for female physicians: Results from course evaluations and alumni studies at MHH].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2014
Same author

Histology and ultrastructure of the lymph nodes of the buffalo (Bos bubalus).

Anatomia, histologia, embryologia·2014
Same author

Expression of caveolin-1 and podocalyxin in rat lungs challenged with 2-kDa macrophage-activating lipopeptide and Flt3L.

Cell and tissue research·2014

Asthma incidence is rising globally, yet its exact causes remain unclear. Current animal models, like mice, do not fully replicate human asthma, necessitating improved research approaches.

Area of Science:

  • Allergy and Immunology
  • Respiratory Medicine
  • Translational Research

Background:

  • Asthma prevalence is increasing in developed nations, affecting both children and adults.
  • The detailed pathophysiology of asthma remains incompletely understood.
  • Existing animal models for asthma research have limitations in fully mimicking human disease.

Purpose of the Study:

  • To discuss the limitations of current animal models, specifically the mouse model, for studying asthma.
  • To outline future research directions for developing more accurate asthma models.

Main Methods:

  • Review and critical analysis of existing literature on asthma animal models.
  • Identification of specific shortcomings of the mouse model in recapitulating human asthma.

Related Experiment Videos

  • Exploration of potential improvements and alternative strategies for asthma research models.

    • Main Results:

    • Current mouse models for asthma partially mimic human disease but exhibit significant differences.
    • Key limitations include disparities in airway hyperresponsiveness, inflammatory profiles, and disease progression.
    • These discrepancies hinder the direct translation of research findings to human clinical applications.

    Conclusions:

    • The limitations of the mouse model necessitate a re-evaluation of its utility in asthma research.
    • Future research should focus on developing more human-relevant asthma models.
    • Advancements in modeling human asthma are crucial for understanding pathophysiology and developing effective therapies.