Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early proliferative changes in intestinal cells.

M Lipkin, E Deschner

    Cancer Research
    |July 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Early colonic lesions show similar cell changes in humans and rodents. Identifying high-risk individuals improves colon cancer detection and diagnosis through phenotyping and numerical analysis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reflections.

    Journal of general internal medicine·2016
    Same author

    Fee-for-service group practice: Further questions.

    Bulletin of the New York Academy of Medicine·2009
    Same author

    Vicinity analysis: a methodology for the identification of similar protein active sites.

    Journal of molecular modeling·2008
    Same author

    Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.

    Oncogene·2007
    Same author

    A randomized trial of teaching clinical skills using virtual and live standardized patients.

    Journal of general internal medicine·2006
    Same author

    Comparison of calcium supplementation or low-fat dairy foods on epithelial cell proliferation and differentiation.

    Nutrition and cancer·2002
    Same journal

    CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.

    Cancer research·2026
    Same journal

    A Clinically Integrated Pediatric Patient-Derived Xenograft Program Enables Evaluation of Cohort and Patient-Specific Biology and Therapeutic Strategies.

    Cancer research·2026
    Same journal

    Editor's Note: Heterodimerization of Insulin-like Growth Factor Receptor/Epidermal Growth Factor Receptor and Induction of Survivin Expression Counteract the Antitumor Action of Erlotinib.

    Cancer research·2026
    Same journal

    Editor's Note: Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

    Cancer research·2026
    Same journal

    Retraction: Two Functional Epitopes of Pigment Epithelial-Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer.

    Cancer research·2026
    Same journal

    Editor's Note: Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells.

    Cancer research·2026
    See all related articles

    Area of Science:

    • Gastroenterology and Oncology
    • Cell Biology
    • Cancer Research

    Background:

    • Early colonic lesions in humans and rodents exhibit comparable epithelial cell proliferative changes.
    • Neoplastic transformation in colonic cells involves progressive abnormal cell development, particularly in rodents exposed to carcinogens and susceptible humans.
    • Understanding these cellular changes is crucial for early cancer detection.

    Purpose of the Study:

    • To identify and classify cells in individuals at high risk for colon cancer.
    • To develop improved methods for detecting and diagnosing neoplasia in high-risk populations.
    • To explore analytical systems for modifying advanced stages of neoplasia.

    Main Methods:

    • Phenotypic identification and classification of colonic epithelial cells.

    Related Experiment Videos

  • Analysis of proliferative changes in early colonic lesions.
  • Development of a precise numerical definition system for neoplastic evolution.

    • Main Results:

    • Similar proliferative changes observed in early colonic lesions across species.
    • Phenotypic classification aids in identifying individuals at increased risk for colon cancer.
    • An analytical system is emerging to aid in modifying advanced neoplasia.

    Conclusions:

    • Phenotypic cell classification is key to improving colon cancer detection in high-risk individuals.
    • Numerical analytical systems show promise in managing advanced stages of neoplasia.
    • Comparative studies of rodent and human colonic lesions offer insights into cancer development.