Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Crossover interference in humans.

E A Housworth¹, F W Stahl

¹Departments of Mathematics and Biology, Indiana University, Bloomington, IN 47405, USA. ehouswor@indiana.edu

American Journal of Human Genetics

|May 29, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Is there variation in crossover interference levels among chromosomes from human males?

Genetics·2009

Same author

Individual, sexual, seasonal, and temporal variation in the amount of sagebrush lizard scent marks.

Journal of chemical ecology·2006

Same author

Alfred Day Hershey.

Biographical memoirs. National Academy of Sciences (U.S.)·2004

Same author

Random sampling of constrained phylogenies: conducting phylogenetic analyses when the phylogeny is partially known.

Systematic biology·2002

Same author

Crossover interference in Arabidopsis.

Genetics·2002

Same author

Heteroduplex rejection in yeast?

Genetics·2000

Same journal

Comparison of methods for assessing effects of risk factors on disease progression in Mendelian randomization under index event bias.

American journal of human genetics·2026

Same journal

Deciding "what" to screen for and "when": The importance of natural history information.

American journal of human genetics·2026

Same journal

Homologous recombination deficiency-driven genomic instability in ovarian cancer as an indicator of BRCA1 and BRCA2 variant pathogenicity.

American journal of human genetics·2026

Same journal

Individuals who deviate from polygenic expectation are enriched for damaging variants in genes linked to rare disease.

American journal of human genetics·2026

Same journal

Integrating social determinants of health and genetic risk in disease risk models.

American journal of human genetics·2026

Same journal

De novo variants in LDB1 are linked to distinct neurodevelopmental phenotypes determined by variant location and differing pathomechanisms.

American journal of human genetics·2026

See all related articles

Researchers found evidence supporting a two-pathway model for crossover interference in humans. This model explains how crossovers are regulated during meiosis, ensuring proper chromosome segregation and genetic diversity.

Area of Science:

Genetics and Molecular Biology
Cell Biology
Reproductive Biology

Background:

Homologous chromosome crossing-over is crucial for accurate chromosome segregation during meiosis I.
Genes involved in crossing-over often also mediate synapsis, the intimate pairing of homologous chromosomes.
Crossover interference regulates crossover distribution, ensuring at least one crossover per chromosome pair.

Purpose of the Study:

To statistically test the two-pathway hypothesis of crossover interference in human data.
To investigate whether different classes of crossovers are subject to interference.

Main Methods:

Statistical analysis of crossover data from the CEPH (Centre d'Etude du Polymorphisme Humain) human genetic reference panel.
Testing the predictions of the two-pathway model against observed crossover patterns.

Related Experiment Videos

Main Results:

The study found statistical evidence supporting the two-pathway hypothesis in humans.
This suggests that not all crossovers are subject to the same interference mechanisms.
The findings align with recent evidence from other model organisms.

Conclusions:

The human genome likely employs a two-pathway system for regulating meiotic crossovers.
This regulation is essential for proper chromosome segregation and genetic recombination.
Further research can explore the molecular basis of these two distinct crossover pathways.