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Updated: Sep 25, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
[Phonomicrosurgical management of the disease of vocal fold]
Xiaobo Zhang1, Dazhang Yang, Naya Wang
1Department of Otorhinolaryngology, China-Japan Friendship Hospital, Beijing 100029, China. jncheng@21cn.com
Objective:
To find a way of reserving normal high quality phonatory function after vocal cord surgery.
Methods:
Various benign lesions (vocal nodules, polyp of vocal cord, cyst of vocal cord, etc) as well as premalignant lesion and early glottic cancer were treated with minimally excision, lateral microflap, medial microflap, submucosal infusion, mucosal stripping or epithelium stripping of phonomicrosurgical techniques to achieve minimally invasion.
Results:
The 1,044 (99.8%) patients suffering from vocal nodules, polyp or cyst and 12 Reinke's edema achieved a normal phonation within a week. The recovery of normal phonation in 20 Reinke's edema, 31 vocal cases needed 1-3 months, by mucosal stripping. The restoration of phonation on 5 papilloma, 36 early malignancy were better than trans-cervical operation. After 5 year follow-up, 3 cases of vocal cord premalignant lesions received the re-stripping operation. 32 cases of early glottic cancer remained tumor free, 5 cases relapsed and 2 cases received the re-stripping operation, and 2 cases received laryngectomy operation.
Conclusion:
The phonomicrosurgery may cure vocal disease and reserves good voice function.
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