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Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
N J A Child1, I A Yang, M C K Pulletz
1Human Genetics Division and Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton, UK.
Biochemical Society Transactions
|May 30, 2003
Abstract:
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 ( TLR4 ) Asp-299-->Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS.