Retinoids: fascinating up-and-coming scenario

Area of Science:

• Dermatology and Pharmacology
• Molecular Biology

Background:

• Retinoids, drugs binding to retinoid receptors, have been significant for 30 years.
• Recent literature presents complex information on retinoids, their receptors, and actions.
• A comprehensive understanding of retinoids requires clear definitions of their facets.

Purpose of the Study:

• To provide a clear and comprehensive overview of retinoids for readers.
• To define retinoid receptors, classification, mode of action, and pharmacological diversity.
• To update information on commonly used systemic and topical retinoids, including newer formulations.

Main Methods:

• Literature review and synthesis of current information on retinoids.
• Detailed definition of retinoid-related facets.
• Inclusion of specific retinoids such as isotretinoin, tretinoin, adapalene, and rexinoids.

Main Results:

• Defined retinoid receptors, classification, mode of action, and pharmacological diversity.
• Reviewed systemic retinoids, their monitoring, adverse effects, and contraindications.
• Highlighted specific retinoids like isotretinoin for acne, topical retinoids, tretinoin formulations, adapalene, and rexinoids.

Conclusions:

• The paper offers an insightful overview of the current landscape of retinoids.
• It addresses common and newer retinoids, their applications, and potential.
• Understanding retinoids, including rexinoids, is crucial for future advancements.