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[Virilism during pregnancy].

K Khiari1, N Ben Abdallah, H Cheikhrouhou

  • 1Service de Néphrologie et de Médecine Interne, Hôpital Charles Nicolle, Tunis, Tunisie.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|May 30, 2003
PubMed
Summary

Pregnancy virilism, caused by hyperandrogeny, can affect female fetuses. This case highlights luteinized thecoma as a rare cause of virilism during pregnancy, with symptoms resolving post-delivery.

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Area of Science:

  • Reproductive Endocrinology
  • Obstetrics and Gynecology

Background:

  • Virilism in pregnancy, characterized by hyperandrogeny, poses risks to the female fetus.
  • Understanding the causes of maternal virilization is crucial for fetal well-being.

Observation:

  • A 28-year-old patient presented with signs of virilization at 18 weeks gestation during a normal pregnancy.
  • Markedly elevated serum testosterone levels were observed.
  • A persistent left ovarian mass was noted post-delivery.

Findings:

  • The ovarian mass was histologically identified as a luteinized thecoma.
  • Luteomas and hyper-reactio luteinalis are identified as primary causes of pregnancy virilism.
  • Thecomas are a rare etiology for virilism in pregnancy.

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Implications:

  • This case underscores the importance of investigating maternal hyperandrogeny during pregnancy.
  • Timely diagnosis and management are essential to mitigate potential fetal effects.
  • Further research into rare causes of virilism in pregnancy is warranted.