Failure of benzoctamine to influence the activity of rat striatum tyrosine-hydroxylase

The influence of benzoctamine (Tacitin) on rat striatum tyrosine-hydroxylase was analized. Injection of 100 mg benzoctamine/kg body weight caused no alteration in the tyrosine-hydroxylase activity whilst a decrease of about 60% in the activity was recorded after treatment with a-methyl-p-tyrosine a known inhibitor of tyrosine-hydroxylase. The present results differ from those of Maitre et al. which indicated that benzoctamine inhibited tyrosine-hydroxylase activity.