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Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
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Impact of stem cell donation modality on normal donor quality of life: a prospective randomized study

G A Kennedy1, J Morton, R Western

  • 1Department of Haematology, Royal Brisbane Hospital, Brisbane, Australia.

Bone Marrow Transplantation
|May 30, 2003
PubMed

Insights

Bone marrow donation caused more localized pain than peripheral blood stem cell (PBSC) collection, but did not delay recovery. Few bone marrow donors experienced chronic pain, and no serious long-term G-CSF related complications were found.

Area of Science:

  • Hematology
  • Transplantation Medicine
  • Clinical Research

Background:

  • Allogeneic stem cell transplantation relies on donor stem cell sources.
  • Granulocyte-colony stimulating factor (G-CSF) is used to mobilize peripheral blood stem cells (PBSCs).
  • Bone marrow (BM) donation is an alternative stem cell source.

Purpose of the Study:

  • To compare donor morbidity and long-term complications between BM and G-CSF stimulated PBSC donation procedures.
  • To assess the impact of donation type on donor pain and recovery.
  • To identify any chronic side effects associated with G-CSF stimulated PBSC donation.

Main Methods:

  • A questionnaire was administered to donors participating in a comparative trial of BM versus PBSC donation.
  • Data collected focused on donor-reported pain, recovery time, and long-term complications.
  • Statistical analysis compared outcomes between the two donation groups.

Main Results:

  • Bone marrow donors reported significantly more localized pain at the donation site compared to PBSC donors.
  • This increased pain did not result in a longer delay for bone marrow donors to return to normal activities.
  • A small percentage of bone marrow donors experienced chronic pain post-donation.
  • No significant long-term adverse effects were identified for G-CSF stimulated PBSC donation.

Conclusions:

  • While bone marrow donation is associated with higher rates of acute localized pain, it does not impede donor recovery.
  • Chronic pain is a potential, albeit infrequent, complication of bone marrow donation.
  • G-CSF stimulated PBSC donation appears safe with no identified serious long-term complications.

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