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Risk factors for piperacillin/tazobactam-resistant Escherichia coli in ICU patients: a clinical study

Ismaël Mohammedi1, Dominique Ploin, Serge Duperret

  • 1Intensive Care Unit, Edouard Herriot Hospital, Claude Bernard University, 69003, Lyon, France. ismael.mohammedi@chu-lyon.fr

Intensive Care Medicine
|May 30, 2003
PubMed
Abstract

Insights

Prior use of amoxicillin or amoxicillin/clavulanate significantly increases the risk of piperacillin/tazobactam-resistant Escherichia coli infections in intensive care unit patients.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Antimicrobial Resistance

Background:

  • Emergence of antibiotic resistance in intensive care units (ICUs) poses a significant threat.
  • Piperacillin/tazobactam is a crucial antibiotic for treating serious Gram-negative infections.
  • Understanding risk factors for resistance is vital for effective treatment strategies.

Purpose of the Study:

  • To identify independent risk factors associated with piperacillin/tazobactam-resistant Escherichia coli (E. coli) in critical care patients.
  • To inform clinical practice and antimicrobial stewardship efforts.

Main Methods:

  • Prospective, consecutive sample survey study conducted in a surgical ICU.
  • Included 133 patients with culture-confirmed E. coli during their ICU stay.
  • Multivariate logistic regression analysis was employed to identify risk factors.

Main Results:

  • Prior use of amoxicillin was a significant independent risk factor (odds ratio, 4.15).
  • Prior use of amoxicillin/clavulanate was also a significant independent risk factor (odds ratio, 3.25).

Conclusions:

  • Treatment with amoxicillin or amoxicillin/clavulanate is a major risk factor for developing piperacillin/tazobactam-resistant E. coli.
  • These findings highlight the importance of judicious antibiotic selection in ICUs to combat resistance.

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