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Differences between d-methamphetamine and d-amphetamine in rats: working memory, tolerance, and extinction.

James R Shoblock1, Isabelle M Maisonneuve, Stanley D Glick

  • 1Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue (MC-136), Albany, NY 12208, USA. ShobloJ@mail.amc.edu

Psychopharmacology
|May 30, 2003
PubMed
Summary

d-amphetamine (AMPH) is more potent than d-methamphetamine (METH) in affecting working memory, with AMPH also showing greater tolerance development. METH uniquely impaired extinction behavior.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • d-amphetamine (AMPH) shows greater potency than d-methamphetamine (METH) in increasing dopamine (DA) in the prefrontal cortex (PFC).
  • Working memory relies on PFC DA, suggesting AMPH may be more potent than METH in affecting cognitive function.

Purpose of the Study:

  • To investigate the differential effects of AMPH and METH on working memory.
  • To compare the potency of AMPH and METH in impacting cognitive performance.

Main Methods:

  • Working memory assessed in rats using a T-maze task with varying delays.
  • Locomotor activity and food reward consumption monitored.
  • Effects of acute and chronic METH and AMPH administration examined, including extinction tests.

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Main Results:

  • AMPH demonstrated greater potency than METH in impairing working memory at a 10s delay.
  • Both drugs initially decreased food reward consumption; AMPH induced tolerance, while METH did not.
  • METH, unlike AMPH, interfered with extinction behavior.

Conclusions:

  • AMPH and METH exhibit distinct effects on working memory and tolerance development.
  • Differences in behavioral inhibition may underlie the observed variations between AMPH and METH.