How an enzyme works
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Updated: Oct 13, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Abstract:
The structure of enzyme active sites and the nature of the catalytic process are reviewed. The impressive efficiency of these protein catalysts appears to stem from such factors as proximity and orientation of enzyme and substrate moieties, strain, and the occurrence of distinctive microenvironments within catalytic centres. Carboxypeptidase, lysozyme, and aspartate transcarbamylase, which have been extensively investigated by many techniques, serve to illustrate the application of these concepts.
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