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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

[Study of herpes viruses in the blood of patients with cardiovascular pathology]

M V Legan, A M Cherniavskiĭ, S P Mironenko

    Klinicheskaia Laboratornaia Diagnostika
    |May 31, 2003
    PubMed

    Insights

    Cytomegalovirus (CMV) is linked to coronary heart disease pathogenesis. Infection rates for CMV and Herpes simplex virus (HSV-1) increase with age in healthy individuals.

    Area of Science:

    • Virology
    • Cardiology
    • Immunology

    Background:

    • Cytomegalovirus (CMV) and Herpes simplex virus type 1 (HSV-1) are common viral infections.
    • Coronary heart disease (CHD) and chronic venous insufficiency (CVI) are significant cardiovascular conditions.

    Purpose of the Study:

    • To investigate the association between CMV and HSV-1 infections and CHD and CVI.
    • To examine the prevalence of CMV and HSV-1 infections across different age groups.

    Main Methods:

    • Immune-enzyme analysis.
    • Polymerase chain reaction (PCR) for viral DNA detection.
    • Immune-fluorescence scanning of atherosclerotic plaques.

    Main Results:

    • A correlation was found between CMV infection and the pathogenesis of coronary heart disease.
    • No significant correlation was observed between CMV or HSV-1 and chronic venous insufficiency.
    • Seropositivity rates for CMV and HSV-1 increased with age in the general population.

    Conclusions:

    • CMV may play a role in the development of coronary heart disease.
    • Age is a factor in the prevalence of CMV and HSV-1 infections.
    • Further research is needed to elucidate the mechanisms of viral involvement in cardiovascular diseases.

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