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Diffuse large B-cell lymphoma: insights gained from gene expression profiling
Izidore S Lossos1, Ronald Levy
1Department of Hematology and Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA.
Abstract:
Analysis of global gene expression with DNA microarrays has great potential to improve the understanding of tumorigenesis advance tumor diagnosis and classification, and affect cancer treatment. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. However, we now realize that the disease is extremely heterogeneous. This review summarizes the progress in understanding DLBCL that has been made as a result of the application of gene expression profiling.
