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Intravital Microscopy Imaging of the Liver following Leishmania Infection: An Assessment of Hepatic Hemodynamics
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Published on: July 28, 2015

Intravascular hemolysis associated with liver disease in a horse with marked neutrophil hypersegmentation

Shashi K Ramaiah1, John W Harvey, Steeve Giguère

  • 1Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0144, USA.

Journal of Veterinary Internal Medicine
|May 31, 2003
PubMed
Abstract

No abstract available in PubMed .

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Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.