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Updated: Sep 25, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Hypercalcemia upon recurrence of renal cell carcinoma producing parathyroid hormone-related protein
Munehisa Ueno1, Shigeki Tokonabe, Isao Kuroda
1Department of Urology, Kidney Disease Center, Saitama Medical Center, Japan. camtmune@saitama-med.ac.jp
Abstract:
We established a new renal carcinoma cell line that produces parathyroid hormone-related protein (PTHrP) and interleukin-6 in culture. The cellular production of PTHrP was confirmed by Northern blot analysis and immunofluorescence examination. Bone and lung metastases occurred simultaneously 3.5 years after surgery. The patient did not show hypercalcemia at this time, despite the presence of multiple osteolytic metastases. About 7 months after bone metastasis was first shown, serum PTHrP was detected by means of an immunoradiometric assay and the calcium level was found to be elevated to 3.29 mmol/l. The hypercalcemia was successfully controlled by i.v. administration of bisphosphonates.
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