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Related Experiment Videos

Tactile stimulus and neurohormonal response: a pilot study.

S Wikström1, T Gunnarsson, C Nordin

  • 1Department of Neuroscience and Locomotion, Division of Psychiatry, University Hospital, Linköping, Sweden. svewi@inr.liu.se

The International Journal of Neuroscience
|May 31, 2003
PubMed
Summary

Massage affects neurohormones differently in men and women. Tactile stimuli increase oxytocin and decrease neuropeptide Y (NPY) in women, with opposite effects observed in men, suggesting sex-specific responses.

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Area of Science:

  • Neuroendocrinology
  • Human Physiology
  • Psychoneuroimmunology

Background:

  • Tactile stimuli, like massage, are known to influence physiological responses.
  • Oxytocin and Neuropeptide Y (NPY) are key neurohormones involved in social bonding, stress, and appetite regulation.
  • Previous research in animal models has suggested neurohormonal changes in response to tactile stimulation, but human data is less conclusive.

Purpose of the Study:

  • To investigate the effects of massage on plasma oxytocin and NPY levels in humans.
  • To explore potential sex differences in the neurohormonal response to tactile stimuli.
  • To compare human responses to findings from animal studies.

Main Methods:

  • Twenty-one healthy volunteers received a standardized massage.

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  • Blood samples were collected immediately before, immediately after, and 60 minutes after the massage.
  • Plasma concentrations of oxytocin and NPY were measured using established laboratory techniques.

    • Main Results:

    • A significant sex difference was observed in the change of oxytocin levels from pre-massage to post-massage.
    • An inverse sex difference was found for changes in NPY levels.
    • These hormonal changes suggest distinct neuroendocrine pathways influenced by sex during tactile stimulation.

    Conclusions:

    • Human responses to tactile stimuli, such as massage, exhibit sex-related differences in neurohormonal profiles.
    • The observed sex-specific patterns of oxytocin and NPY modulation contradict some findings from animal studies.
    • These results highlight the complexity of the human neuroendocrine system's response to physical touch.