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Herpes simplex virus latency-associated transcript gene function.

Jennifer R Kent1, Wen Kang, Cathie G Miller

  • 1Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6076, USA.

Journal of Neurovirology
|May 31, 2003
PubMed
Summary
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Herpes simplex virus type 1 (HSV-1) latency in neurons involves latency-associated transcripts (LATs). This review explores how LATs interact with apoptosis, potentially influencing HSV-1 persistence.

Area of Science:

  • Virology
  • Molecular Biology
  • Neuroscience

Background:

  • Herpes simplex virus type 1 (HSV-1) establishes lifelong latency in human neuronal cells.
  • Latency-associated transcripts (LATs) are crucial for maintaining HSV-1 latency.
  • Understanding LATs' role is key to deciphering viral persistence.

Purpose of the Study:

  • To review recent findings on the LAT region's involvement in apoptotic pathways.
  • To explore the relationship between LATs, apoptosis, and other LAT functions during HSV-1 latency.

Main Methods:

  • Literature review of recent studies on HSV-1 LATs.
  • Analysis of research linking LATs to cellular apoptosis.
  • Synthesis of information on potential LAT functions.

Related Experiment Videos

Main Results:

  • LATs are implicated in modulating apoptotic pathways during HSV-1 infection.
  • Evidence suggests LATs may promote neuronal cell survival, aiding viral persistence.
  • LATs likely possess multifaceted roles beyond just apoptosis regulation.

Conclusions:

  • The LAT region plays a significant role in managing apoptosis during HSV-1 latency.
  • LATs' interaction with apoptotic pathways is critical for viral persistence in neurons.
  • Further research into LATs' diverse functions is warranted.