Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins and plaque stability.

Mardi Gomberg-Maitland1, Valentin Fuster, Zahi Adel Fayad

  • 1Mount Sinai Medical Center, Department of Cardiology, New York, NY 10129, USA. mardi.gomberg@msnyuhealth.org

Journal of Cardiovascular Risk
|May 31, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

REVEALing New Standards: Low Risk Redefined.

JACC. Heart failure·2026
Same author

Sotatercept Safety and Efficacy in Intermediate- to Low-Risk Pulmonary Arterial Hypertension: A Pooled Analysis of PULSAR and STELLAR.

Chest·2026
Same author

Mitral Transcatheter Edge-to-Edge Repair Using Novel Augmented Imaging Software.

JACC. Case reports·2026
Same author

Sotatercept for Combined Post- and Precapillary Pulmonary Hypertension Associated With Heart Failure: Results From the Phase 2, Randomized, Placebo-Controlled CADENCE Study.

Circulation·2026
Same author

Artificial intelligence based fusion imaging streamlining mitral transcatheter edge-to-edge repair.

European heart journal. Imaging methods and practice·2026
Same author

Pulmonary Hypertension Associated With Left Heart Disease: Challenges, Emerging Strategies, and Future Directions.

Journal of the American College of Cardiology·2026
Same journal

Hair loss, insulin resistance, and heredity in middle-aged women. A population-based study.

Journal of cardiovascular risk·2003
Same journal

Alcohol use and cardiovascular disease preventive services.

Journal of cardiovascular risk·2003
Same journal

Clustering of cardiovascular risk factors and risk of development of hypertension in Japanese male office workers.

Journal of cardiovascular risk·2003
Same journal

Are heart disease patients more likely to have healthy lifestyle behaviors? Results from the 2000 Behavioral Risk Factor Surveillance Survey.

Journal of cardiovascular risk·2003
Same journal

Social relations in women with coronary heart disease: the effects of work and marital stress.

Journal of cardiovascular risk·2003
Same journal

Are anti-Chlamydia pneumoniae antibodies prognosis indicators for peripartum cardiomyopathy?

Journal of cardiovascular risk·2003
See all related articles

Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are standard treatments for high cholesterol. They effectively lower cardiovascular risks through various mechanisms beyond just lipid reduction.

Area of Science:

  • Cardiology
  • Pharmacology
  • Biochemistry

Background:

  • Hypercholesterolaemia poses significant cardiovascular risks.
  • 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, known as statins, are a cornerstone therapy.
  • Statins have demonstrated efficacy in reducing cardiovascular morbidity and mortality.

Purpose of the Study:

  • To review the pharmacology of statin therapy.
  • To summarize key clinical trial findings for statins.
  • To explore the non-lipid-lowering mechanisms of HMG-CoA reductase inhibition in cardiovascular health.

Main Methods:

  • Literature review of pharmacological data.
  • Analysis of major clinical trials on statin efficacy.
  • Synthesis of research on cardiovascular benefits of HMG-CoA reductase inhibition.

Related Experiment Videos

Main Results:

  • Statins are established as the standard of care for hypercholesterolaemia.
  • Clinical trials confirm statins' role in reducing cardiovascular events.
  • Evidence supports multiple pathways through which statins benefit the cardiovascular system, independent of lipid lowering.

Conclusions:

  • Statin therapy is crucial for managing hypercholesterolaemia and reducing cardiovascular disease.
  • Understanding the diverse mechanisms of statins enhances their clinical application.
  • Further research into non-lipid effects of statins may reveal additional therapeutic benefits.