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Updated: Sep 25, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
The role of stents in patients with carotid disease
1Department of Vascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Insights
Carotid endarterectomy offers benefits for significant stenosis but carries risks. Carotid stenting is a less invasive alternative showing similar outcomes, especially for high-risk patients.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Cerebrovascular Disease
Background:
- Carotid endarterectomy is a common procedure for carotid bifurcation stenosis, providing significant clinical benefit.
- High rates of morbidity and mortality are associated with carotid endarterectomy in patients with comorbidities or complex anatomy.
Purpose of the Study:
- To evaluate carotid stenting as a less invasive alternative to carotid endarterectomy.
- To compare the outcomes of carotid stenting versus endarterectomy in patients with carotid stenosis.
Main Methods:
- Ongoing clinical trials, including randomized controlled trials and registry-based studies.
- Analysis of initial results from ongoing research comparing carotid stenting and endarterectomy.
Main Results:
- Initial findings suggest comparable outcomes between carotid stenting and carotid endarterectomy for most patients.
- Carotid stenting may provide additional clinical benefits for patients at high risk for open surgical procedures.
Conclusions:
- Carotid stenting emerges as a viable, less invasive option for managing carotid stenosis.
- Further research is ongoing to fully establish the role and long-term efficacy of carotid stenting compared to endarterectomy.
Abstract:
Carotid endarterectomy, the most commonly performed peripheral vascular surgical procedure, is associated with substantial clinical benefit when performed in patients with significant carotid bifurcation stenotic disease. The rate of morbidity and mortality, however, is significant when performed in patients with medical comorbidities or challenging surgical anatomy. Carotid stenting has emerged as a less invasive alternative to traditional endarterectomy. A large number of clinical trials, both randomized and registry-based, are ongoing. Initial results suggest that the outcome of carotid stenting may be identical to that of endarterectomy in most patients and may also offer additional clinical benefit in patients at high risk from an open surgical approach.
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