Related Experiment Videos
Differential molecular profiling between skin carcinomas reveals four newly reported genes potentially implicated in
Claire Marionnet1, Claude Lalou, Karine Mollier
1INSERM U532, Hôpital Saint-Louis, Paris, France.
Oncogene
|May 31, 2003
Abstract:
Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are skin tumors with different invasive potential. In this work, we analysed mRNA differential expression between seven BCC and five SCC and their normal skin counterparts using 1176 cDNA macroarrays and verification by RT-PCR to identify genes modulated in each tumor type. We identified 37 genes commonly modulated in both tumors and four genes specifically modulated in SCC. Among these latter RhoC and EMMPRIN genes seem to be of particular interest and could participate in SCC aggressivity.