Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

TREMs in the immune system and beyond.

Marco Colonna¹

¹Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA. mcolonna@pathbox.wustl.edu

Nature Reviews. Immunology

|May 31, 2003

Summary

Triggering receptors expressed by myeloid cells (TREMs) are key immune regulators. TREM2 deficiency causes severe bone and neurological diseases, indicating roles beyond immunity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.

Nature cancer·2025

Same author

Myofibroblastic CAFs arising from bone-resident osteoblast precursors retain an osteolineage signature and support breast cancer progression via Osterix-mediated signaling.

bioRxiv : the preprint server for biology·2025

Same author

SLC7A8 is essential for metabolic fitness and function of Th2 cells.

The Journal of experimental medicine·2025

Same author

Membrane IL-18 identifies a human macrophage subset with distinct proteomic and functional traits.

Oncoimmunology·2025

Same author

Dual threat: VSIG4⁺ macrophages use IL-11 and VSIG4 to silence T cells.

Developmental cell·2025

Same author

Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature.

Nature communications·2025

Area of Science:

Immunology
Cell Biology
Neuroscience

Background:

Triggering receptors expressed by myeloid cells (TREMs) are a growing family of activating and inhibitory receptors.
TREM1 and TREM2 signal via the adaptor protein DAP12 to activate myeloid cells.
TREM1 amplifies inflammation against bacterial and fungal infections.

Purpose of the Study:

To investigate the functions of TREM1 and TREM2.
To understand the implications of TREM2 deficiency in disease.

Main Methods:

The abstract does not specify methods.

Main Results:

TREM2 activates monocyte-derived dendritic cells and regulates osteoclast development.
TREM2 deficiency results in bone cysts and central nervous system demyelination, leading to dementia.

Conclusions:

TREM1 and TREM2 play critical roles in immune responses and myeloid cell activation.
TREM2's function extends beyond the immune system, impacting bone and neurological health.

Related Experiment Videos