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Sequence-based cancer genomics: progress, lessons and opportunities.

Robert L Strausberg1, Andrew J G Simpson, Richard Wooster

  • 1National Cancer Institute, 31 Center Drive, Room 10A07, Bethesda, Maryland 20892, USA. RLS@nih.gov

Nature Reviews. Genetics
|May 31, 2003
PubMed
Summary
This summary is machine-generated.

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Genome-wide technologies offer new insights into cancer cell biology. Collaborative efforts are building integrated, accessible databases for cancer research applications.

Area of Science:

  • Genomics
  • Cancer Biology
  • Bioinformatics

Background:

  • Genome-wide technologies provide comprehensive molecular insights into cancer cells.
  • Developing public databases is crucial for organizing and sharing cancer genomic data.
  • Understanding cancer genome alterations and expression is key for research.

Purpose of the Study:

  • To describe collaborative initiatives for integrated cancer genome databases.
  • To enhance accessibility of cancer research data for the scientific community.
  • To facilitate basic and applied cancer research through shared data.

Main Methods:

  • Synergistic efforts between international research programs (Brazil, UK, US).
  • Development of integrated databases for cancer genome and expression data.

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  • Focus on creating widely accessible platforms for researchers.

    • Main Results:

    • Establishment of collaborative frameworks for data sharing.
    • Progress towards building comprehensive, integrated cancer genome databases.
    • Increased accessibility of cancer-related molecular data.

    Conclusions:

    • Integrated, accessible databases are essential for advancing cancer research.
    • International collaboration accelerates the development of critical cancer research resources.
    • These databases will support diverse applications in basic and applied cancer science.