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Updated: Aug 15, 2026

Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 19, 2013
Sequence-based cancer genomics: progress, lessons and opportunities
Robert L Strausberg1, Andrew J G Simpson, Richard Wooster
1National Cancer Institute, 31 Center Drive, Room 10A07, Bethesda, Maryland 20892, USA. RLS@nih.gov
Abstract:
Technologies that provide a genome-wide view offer an unprecedented opportunity to scrutinize the molecular biology of the cancer cell. The information that is derived from these technologies is well suited to the development of public databases of alterations in the cancer genome and its expression. Here, we describe the synergistic efforts of research programmes in Brazil, the United Kingdom and the United States towards building integrated databases that are widely accessible to the research community, to enable basic and applied applications in cancer research.
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