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[Study on the compatibility of composite herbal medicines of the lingguizhugan decoction]
Zong-hua Song1, Shu-jia Dai, Hui-qin Li
1Shenyang Pharmaceutical University, Shenyang 110015, Liaoning, China.
Objective:
To study the compatibility of composite herbal medicines of the Ling Gui Zhu Gan Decoction.
Method:
Ethanol extract test solutions of the different combinations were prepared according to the orthogonal layout L16(4(5)). Pharmacologic experiments, such as the time of surviving of mice in shortage of oxygen in regular air pressure, the antagonizing effect on arrhythmia induced by chloroform and diuresis were carried out with the solutions. Variance analysis, canonical correlation and stepwise regression analysis were applied to interrelate the amount of each drug and the pharmacologic data.
Result:
The results confirmed that Fuling and Guizhi are the basis, while Baizhuand Gancao are the adjuvans, which is conformed to the theory of TCM.
Conclusion:
This study provides a significant try for studying the compatibility of composite herbal medicines.