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Updated: Jul 11, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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[Study on the preparation of venenum bufonis beta-cyclodextrin inclusion complexes].

Tao Guo¹, Hong-tao Song, Ming-hong Zhao

¹Shenyang Military General Hospital, Shenyang 110016, Liaoning, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|June 5, 2003

Summary

The ball grinding method is optimal for preparing Venenum Bufonis beta-cyclodextrin inclusion complexes, achieving a high bufadienolide inclusion rate of 85.42%. This method enhances the efficacy of Venenum Bufonis preparations.

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Area of Science:

Pharmacology and Pharmaceutical Sciences
Natural Product Chemistry

Context:

Venenum Bufonis is a traditional Chinese medicine with therapeutic potential.
Beta-cyclodextrin is widely used to improve the solubility and bioavailability of poorly soluble drugs.
The preparation of inclusion complexes is crucial for enhancing drug delivery and efficacy.

Purpose:

To investigate and optimize the preparation of Venenum Bufonis beta-cyclodextrin inclusion complexes.
To compare the efficacy of different preparation methods for these complexes.
To determine the optimal method for achieving a high inclusion rate of bufadienolides.

Summary:

The study optimized conditions for Venenum Bufonis beta-cyclodextrin inclusion complex preparation using uniform design.
Five different preparation methods were evaluated.
The ball grinding method demonstrated superior performance, yielding an 85.42% bufadienolide inclusion rate.

Impact:

Identifies the ball grinding method as the most effective for Venenum Bufonis beta-cyclodextrin inclusion complex preparation.
Provides a foundation for developing improved Venenum Bufonis-based pharmaceuticals.
Highlights the potential for enhanced therapeutic outcomes through optimized drug delivery systems.