Related Experiment Video
Updated: Aug 15, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
Published on: November 8, 2015
Cyclosporine bioavailability of two physically different oral formulations
P Postolache1, O Petrescu, V Dorneanu
1University of Medicine and Pharmacy, Clinical Pharmacology, Iasi, Romania .
Abstract:
To assess the comparative bioavailability of two cyclosporine capsule products with different pharmaceutical formulation an open randomized two-period cross over study was conducted in 24 healthy volunteers. Our results, obtained from cyclosporine HPLC determination onto the whole blood samples collected, show that the test cyclosporine non-SMEDDS formulation was not bioequivalent cyclosporine SMEDDS formulation due to a statistically significantly lower absorption rate. The outcome does not support free and full interchangeability in chronic stable graft recipients of the two products studied, unless validated clinical and laboratory conversion protocols for each kind of organ transplantation are enforce.
More Related Videos
Related Concept Videos
Bioavailability: Overview
Bioequivalence: Overview
Bioavailability: Overview
Bioavailability: Influencing Factors
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Modified-Release Drug Delivery Systems: Bioavailability

