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Hepatitis B and C single and co-infection in chronic liver disease and their effect on the disease pattern

N Bukhtiari1, T Hussain, M Iqbal

  • 1Pakistan-US Laboratory for Sero-Epidemiology, Army Medical College, Rawalpindi.

JPMA. the Journal of the Pakistan Medical Association
|June 5, 2003
PubMed

Insights

Chronic liver disease (CLD) patients frequently have hepatitis B virus (HBV) or hepatitis C virus (HCV) infections, often co-occurring. Coinfection with HBV and HCV in CLD patients indicates more severe disease.

Area of Science:

  • Hepatology
  • Virology
  • Internal Medicine

Background:

  • Chronic liver disease (CLD) poses a significant global health burden.
  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of CLD.
  • Understanding the prevalence and impact of HBV and HCV coinfection in CLD is crucial for patient management.

Purpose of the Study:

  • To determine the frequency of HBV and HCV infections and their coinfection in adult CLD patients.
  • To investigate differences in clinical features between single and coinfections in CLD.
  • To assess the utility of seromarkers for HBV and HCV detection in CLD.

Main Methods:

  • Retrospective study of adult CLD patients admitted to Military Hospital, Rawalpindi (1999-2000).
  • Data collection included patient history and clinical features.
  • Serological markers for HBV (HBsAg, anti-HBc) and HCV (anti-HCV) were analyzed.

Main Results:

  • Ninety-seven CLD patients (mean age 51.6 years) were included.
  • Prevalence of HBV and/or HCV infection was high, with 90% of patients showing evidence of infection.
  • Coinfection was common, with 7.2% positive for HBsAg and anti-HCV, and 35.1% positive for anti-HCV and anti-HBc.

Conclusions:

  • A high proportion of CLD patients have evidence of HBV, HCV, or coinfection.
  • Coinfection with HBV and HCV is associated with more severe CLD.
  • Anti-HBc is a sensitive marker for past HBV infection in CLD patients.
Abstract

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