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Secretory meningiomas.

Nagihan Colakoğlu1, Eren Demirtaş, Nezih Oktar

  • 1Department of Pathology, School of Medicine, Pamukkale University, Denizli, Turkey. nagihancol@yahoo.com

Journal of Neuro-Oncology
|June 5, 2003
PubMed
Summary

Secretory meningiomas, a rare subtype, predominantly affect females and show no recurrence. These tumors exhibit distinct histological and clinical features compared to other meningiomas.

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Area of Science:

  • Neuro-oncology
  • Pathology
  • Endocrinology

Background:

  • Secretory meningiomas represent a rare subtype of meningioma, accounting for 1.6% of all cases.
  • This subtype exhibits a predilection for female patients, with a reported ratio of 3:1.
  • Distinct clinical and histological characteristics differentiate secretory meningiomas from other meningioma types.

Purpose of the Study:

  • To investigate the clinicopathological features of secretory meningiomas.
  • To analyze the immunohistochemical profile of secretory meningiomas, focusing on specific markers.
  • To compare the characteristics of secretory meningiomas with other meningioma subtypes.

Main Methods:

  • Retrospective analysis of clinical data from patients diagnosed with secretory meningiomas.

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  • Immunohistochemical staining for markers including Ki-67, progesterone receptor, carcinoembryonic antigen, cytokeratin, epithelial membrane antigen, human milk fat globulin 2, CA125, alpha-1-antitripsin, and ubiquitin.
  • Evaluation of tumor recurrence and patient follow-up data over a 24-180 month period.

    • Main Results:

    • A low Ki-67 proliferative index (0.3%) and no reported recurrences during follow-up (24-180 months).
    • Positive progesterone receptor in 33% of cases.
    • Consistent positivity for carcinoembryonic antigen, cytokeratin, and epithelial membrane antigen in inclusions and surrounding cells.
    • High positivity (92%) for human milk fat globulin 2.
    • Variable positivity for CA125, alpha-1-antitripsin, and ubiquitin (83% in inclusions).

    Conclusions:

    • Secretory meningiomas possess unique histological and clinical features.
    • The low proliferative index and lack of recurrence suggest a benign clinical course.
    • Immunohistochemical findings highlight specific markers that aid in the diagnosis and classification of this rare meningioma subtype.