Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pentobarbital elimination in patients with poor renal function.

M M Reidenberg, D T Lowenthal, W Briggs

    Clinical Pharmacology and Therapeutics
    |July 1, 1976
    PubMed
    Summary

    Pentobarbital drug elimination is normal in renal failure patients. Some uremic patients exhibit shorter half-lives (T/2) due to reduced distribution volume, not accelerated metabolism, indicating normal pentobarbital clearance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A metabolomic study of adipose tissue in mice with a disruption of the circadian system.

    Molecular bioSystems·2015
    Same author

    Should administration of coenzyme Q10 be recommended to patients with congestive heart failure?

    Clinical pharmacology and therapeutics·2014
    Same author

    Cigarette smoking, coffee drinking, and ingestion of charcoal-broiled beef as potential modifiers of drug therapy and confounders of clinical trials.

    The Journal of pharmacology and experimental therapeutics·2012
    Same author

    From adverse drug reactions to drug disposition to WHO and essential medicines to our discipline of clinical pharmacology.

    Clinical pharmacology and therapeutics·2010
    Same author

    Can the selection and use of essential medicines decrease inappropriate drug use?

    Clinical pharmacology and therapeutics·2009
    Same author

    Phytochrome-driven changes in respiratory electron transport partitioning in soybean (Glycine max. L.) cotyledons.

    Plant biology (Stuttgart, Germany)·2008

    Area of Science:

    • Pharmacokinetics
    • Nephrology
    • Drug Metabolism

    Background:

    • Drug oxidation is reportedly variable in uremic patients, contrasting with animal studies.
    • Understanding pentobarbital's behavior in renal failure is crucial for patient management.

    Purpose of the Study:

    • To investigate pentobarbital's pharmacokinetic parameters in uremic patients.
    • To determine if drug oxidation is altered in renal failure.

    Main Methods:

    • Oral administration of 100 mg pentobarbital to 11 normal subjects and 9 uremic patients.
    • Serial blood sampling over 36 hours post-dose.
    • Plasma pentobarbital concentration measurement using gas-liquid chromatography (GLC).
    • Determination of plasma half-life (T/2) and apparent volume of distribution (aVD).

    Related Experiment Videos

    Main Results:

    • Mean T/2 was 26.5 hours in normals and 21.3 hours in uremic patients.
    • Four uremic patients showed T/2 values below the normal range.
    • Apparent volumes of distribution (aVD) were similar between groups (62 L vs. 58 L).
    • Metabolic clearance rates were normal in most uremic patients with short T/2, linked to smaller aVD.

    Conclusions:

    • Pentobarbital elimination is not accelerated in renal failure.
    • Shortened pentobarbital T/2 in some uremic patients is likely due to a reduced apparent volume of distribution, not increased metabolism.
    • Drug clearance remains normal in uremia despite variations in T/2.