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Severe systemic reaction to (99m)Tc-methylene diphosphonate: a case report
Kottekkattu K Balan1, Arabinda K Choudhary, Anupama Balan
1Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom. kottekkattu.balan@addenbrookes.nhs.uk
Journal of Nuclear Medicine Technology
|June 5, 2003
Summary
A severe systemic reaction occurred in a woman following a technetium-99mTc-methylene diphosphonate bone scan. This reaction involved liver and kidney dysfunction and skin issues, possibly due to an immune response.
Area of Science:
- Nuclear Medicine
- Radiopharmaceuticals
- Immunology
Background:
- Bone scintigraphy using technetium-99mTc-methylene diphosphonate is a common diagnostic imaging procedure.
- Adverse reactions to radiopharmaceuticals are rare but can be severe.
Observation:
- A patient experienced an unusual severe systemic reaction post-bone scan.
- The reaction included diffuse increased radiotracer uptake in the liver and kidneys.
- Dermatologic manifestations and reversible organ dysfunction were also noted.
Findings:
- The observed systemic reaction was severe and lacked an alternative explanation.
- Imaging revealed abnormal radiotracer distribution in the liver and kidneys.
- Clinical presentation included skin changes and temporary organ impairment.
Implications:
- This case highlights a rare but significant adverse event associated with technetium-99mTc-methylene diphosphonate bone scans.
- The findings suggest a potential immune-mediated mechanism for such reactions.
- Further investigation into radiopharmaceutical hypersensitivity is warranted.