Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms and methods to resolve edge effect.

Pramod Kuchulakanti1, Robert Lew, Ron Waksman

  • 1Division of Cardiology, Washington Hospital Center, Washington, DC 20010, USA. ron.waksman@medstar.ne

The Journal of Invasive Cardiology
|June 5, 2003
PubMed
Summary

Vascular brachytherapy effectively treats in-stent restenosis by addressing issues like late thrombosis with antiplatelet therapy and edge effects through precise radiation delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fixed <i>vs</i> weight-based heparin dosing in stable patients undergoing diagnostic coronary physiology studies.

World journal of cardiology·2026
Same author

A brief visual evoked potential (VEP) modulation assessment of experience-dependent plasticity recorded via wireless dry-EEG headset in Phase 1 clinical units.

Scientific reports·2026
Same author

An open-label study on ulotaront's effects on insulin-glucose regulation in schizophrenia patients with metabolic syndrome and prediabetes: Part I.

Diabetes, obesity & metabolism·2025
Same author

A double-blind study on ulotaront's impact on weight-related parameters in schizophrenia patients with metabolic syndrome and prediabetes: Part II.

Diabetes, obesity & metabolism·2025
Same author

Discovery and Model-Informed Drug Development of a Controlled-Release Formulation of Nonracemic Amisulpride that Reduces Plasma Exposure but Achieves Pharmacodynamic Bioequivalence in the Brain.

Clinical pharmacology and therapeutics·2024
Same author

TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes.

Diabetes, obesity & metabolism·2024

Area of Science:

  • Cardiovascular medicine
  • Interventional cardiology
  • Radiation oncology

Background:

  • In-stent restenosis (ISR) is a significant challenge following percutaneous coronary intervention.
  • Vascular brachytherapy (VBT) has emerged as a key treatment for ISR.
  • Previous limitations of VBT have been largely overcome.

Observation:

  • Late thrombosis, a complication of VBT, has been substantially mitigated.
  • Prolonged antiplatelet therapy is crucial for managing late thrombosis.
  • Edge effect, caused by insufficient radiation coverage, remains a concern.

Findings:

  • The edge effect in VBT is attributed to inadequate radiation coverage at the lesion margins.
  • Strategies to overcome the edge effect involve precise injury confinement to the lesion segment.

Related Experiment Videos

  • Extending radiation sources beyond the injured segment can improve coverage.

    • Implications:

    • Optimized VBT techniques can enhance treatment efficacy for ISR.
    • Careful radiation planning is essential to minimize VBT-related complications.
    • Further research may refine VBT protocols for improved patient outcomes in ISR treatment.