Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Androgen and bone mass in men.

Annie W C Kung1

  • 1Department of Medicine, University of Hong Kong, Rm 420, Block K, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, China. awckung@hkucc.hku.hk

Asian Journal of Andrology
|June 5, 2003
PubMed
Summary

Androgens significantly impact bone health throughout life, promoting growth and influencing bone cell activity. Testosterone, converted to estrogen, plays a crucial role in maintaining bone mass and structure in men.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Handgrip strength and risk of common infections and sepsis: Two prospective cohorts with proteomic mediation analysis.

Archives of gerontology and geriatrics·2026
Same author

Low Bone Mineral Density as a Risk Factor for Liver Cirrhosis.

The Journal of clinical endocrinology and metabolism·2024
Same author

Levothyroxine Treatment Among Pregnant Women and Risk of Seizure in Children: A Population-Based Cohort Study.

Drug safety·2023
Same author

Association of maternal levothyroxine use during pregnancy with offspring birth and neurodevelopmental outcomes: a population-based cohort study.

BMC medicine·2022
Same author

Hip Fracture as a Predictive Marker for the Risk of Dementia: A Population-Based Cohort Study.

Journal of the American Medical Directors Association·2022
Same author

Low Bone Mineral Density With Risk of Dementia: A Prospective Cohort Study.

Journal of the American Medical Directors Association·2022

Area of Science:

  • Endocrinology
  • Bone Biology
  • Skeletal Physiology

Background:

  • Androgens exert diverse effects on the skeleton across the lifespan.
  • They are critical for skeletal development during puberty and adolescence.
  • Androgens modulate osteoblast and osteoclast functions through intricate pathways.

Purpose of the Study:

  • To elucidate the multifaceted roles of androgens in skeletal physiology.
  • To highlight the mechanisms by which androgens influence bone growth, mineral accumulation, and bone cell activity.
  • To emphasize the significance of androgen aromatization to estrogens in mediating skeletal effects.

Main Methods:

  • Review of existing literature on androgen and estrogen actions on bone.
  • Analysis of studies investigating androgen effects on osteoblast and osteoclast function.
  • Examination of the role of aromatization in testosterone's skeletal actions.

Main Results:

  • Androgens promote skeletal growth and mineral accretion during puberty and adolescence.
  • They stimulate osteoblasts while suppressing osteoclast activity and lifespan.
  • Androgens increase periosteal bone apposition, leading to larger bone size and thicker cortical bone in males.
  • Aromatization of testosterone to estrogens is a key pathway for androgen's bone effects.
  • Estrogen is the primary regulator of bone resorption in men, with both hormones vital for bone formation.

Conclusions:

  • Androgens are essential regulators of skeletal health and bone remodeling throughout life.
  • The conversion of testosterone to estrogen is a critical mechanism for androgen's beneficial effects on bone.
  • Both testosterone and estrogen are indispensable for maintaining bone formation and overall skeletal integrity.

Related Experiment Videos