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Biarylpyrimidines: a new class of ligand for high-order DNA recognition
Peter M Murphy1, Victoria A Phillips, Sharon A Jennings
1School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK BD7 1DP.
Chemical Communications (Cambridge, England)
|June 5, 2003
Abstract:
Biarylpyrimidines bearing omega-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.