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Related Experiment Videos

[A new vomiting animal model--mink].

Wang Yue1, Fang Zhang, Lei Wang

  • 1Department of Pharmacology, Medical College of Qingdao University, Qingdao University, Qingdao 266021, China.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|June 5, 2003
PubMed
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Researchers developed a new mink model for studying vomiting. This model effectively demonstrated antiemetic drug efficacy, aiding in the development of new treatments.

Area of Science:

  • Pharmacology
  • Animal Models
  • Gastroenterology

Context:

  • Vomiting is a complex physiological response with significant clinical implications.
  • Existing animal models for studying emesis have limitations.
  • Minks (Mustela vison) offer a novel platform for emesis research.

Purpose:

  • To establish a reliable and reproducible vomiting model in adult male minks.
  • To validate the efficacy of common emetic agents (cisplatin, apomorphine, copper sulfate, X-radiation) in inducing vomiting.
  • To assess the antiemetic potential of ondansetron and metoclopramide in this new model.

Summary:

  • Adult male minks were utilized to establish a vomiting model using various emetic agents.
  • Cisplatin (7.5 mg/kg i.p.), apomorphine (1.6 mg/kg s.c.), and copper sulfate (40 mg/kg i.g.) successfully induced vomiting.

Related Experiment Videos

  • Pretreatment with ondansetron and metoclopramide significantly inhibited retching and vomiting (P < 0.05, P < 0.01).
  • Immunohistological analysis of 5-hydroxytryptamine (5-HT) in the ileum was performed post-behavioral experiments.

    • Impact:

    • The mink vomiting model provides a valuable new tool for investigating the mechanisms of emesis.
    • This model can be instrumental in the screening and development of novel antiemetic drugs.
    • Further research utilizing this model may lead to improved therapeutic strategies for managing nausea and vomiting.