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Published on: August 2, 2024
Possible role of matriptase in the diagnosis of ovarian cancer
Michael D Johnson1, Michael D Oberst, Chen-Yong Lin
1Department of Oncology, Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA. johnsom@georgetown.edu
Abstract:
There are increasing data that suggest a role for the serine protease matriptase and its inhibitor, hepatocyte growth factor activator inhibitor-1, in the pathogenesis and progression of ovarian cancer. This review will discuss the matriptase/inhibitor system in the context of ovarian cancer and examine the possibility that this system might be a useful therapeutic and/or diagnostic target in this disease.
